The aim is to provide a practical approach to the risk assessment of the QT interval, including the measurement, heart rate correction and determining when the QT is abnormal. The congenital long QT syndrome (LQTS) is an inheritable cardiac arrhythmia disorder with a prevalence of 1 per 2000 persons, and is associated with sudden cardiac death attributable to malignant ventricular arrhythmias. This review will focus on the assessment of drug-induced effects on the QT interval in an individual patient following either therapeutic use or an overdose of a drug. 1,2 Prolongation of the QT interval corrected for heart rate (QTc interval) is the hallmark of the clinical diagnosis of LQTS, 3 mirroring a prolonged repolarization caused by mutations in genes … E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs October 2005

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