The first step in this reaction is forming the conjugate base of the alcohol (called an alcoxide) by reacting the alcohol with sodium metal. Data and results Compound Amount used MW (g/mol) Moles Stoichiometry/Comments acetaminophen 0.354 g … Show reaction between Acetaminophen with NaOH and Phenacetin with NaOH.

The goal of this lab is to use the Willi amson ether synthesis and prepare a phenacetin. Lab 10: Williamson Ether Synthesis: Preparation of Phenacetin from Acetaminophen Erica Li (Lab Partner: Sankhya A.) CH3CH2l H OH K2CO3 methyl ethyl ketone acetaminophen phenacetin . The first step in this reaction is forming the conjugate base of the alcohol (called an alcoxide) by reacting the alcohol with sodium metal.

Introduction. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Shrestha Abstract The objective of the experiment was to synthesize acetaminophen and use it to synthesize phenacetin.

In the synthesis of Phenacetin, what is the purpose of extracting the organic layer with 1 M sodium hydroxide solution? The Williamson ether synthesis is a reaction that converts alcohols (R-OH) into ethers (R-O-R). Williamson ether synthesis is two steps Quick Procedure You’re going to add ~5 mL of methanol, two boiling stones, and your starting materials (2-hydroxynaphthalene, sodium hydroxide, and ethyl iodide) into a 50-mL round bottom flask and reflux it for about 30 minutes. The theoretical yield for the reaction was 1.54 g, and the experimental yield was 0.56g. phenols.

Tylenol) into phenacetin to exemplify a Williamson ether synthesis. Phenacetin will then be subjected to an electrophilic aromatic substitution (EArS) reaction to introduce a bromine into the ring at a yet to be determined position. In this experiment, students will convert the acetaminophen from an Extra Strength Tylenol tablet into phenacetin to exemplify a Williamson ether synthesis. Bromoethane: 1.6 g molar mass: 108.97 g/mol. With the theoretical and experimental yield obtained, the percent yield was calculated and found to be 36.36 %. The Williamson ether synthesis is a reaction that converts alcohols (R-OH) into ethers (R-O-R). The procedure stated in Chem 2120 experiment 6 Williamson Ether Synthesis of Phenacetin laboratory manual was followed without any major changes. (Potassium carbonate is at best sparingly soluble in the solvent used and increasing its surface area facilitates the deprotonation of acetaminophen). ... What is a williamson ether synthesis? Which are stronger--phenols or alcohols? Williamson Ether Synthesis. July 25, 2016 Methods and Background The purpose of this experiment is to prepare phenacetin by Williamson ether synthesis of acetaminophen using iodoethane and potassium carbonate.

Calculate the percent yield of phenacetin obtained from the Williamson ether synthesis. Organic Chemistry Lab: Williamson Ether Synthesis of Phenacetin 1. It uses an alkoxide ion to attack an alkyl halide, substituting the alkoxy (―O―R) group for…

Expert Answer 100% (5 ratings) Previous question Next question Transcribed Image Text from this Question. 2. Overview of two-step synthesis of bromophenacetin from acetaminophen.

Procedure: To a 5-mL conical vial equipped with a spin vane, weigh 100 mg of acetaminophen and 180 mg of powdered anhydrous potassium carbonate (K2CO3). Purification will be Phenacetin can be prepared by using Williamson Ether Synthesis with the help of acetaminophen and ethyl iodide (CH 3 CH 2 I) in the presence of a base like NaOH.. Phenacetin is prepared by taking Acetaminophen (which is in Ty lenol), and mix it with iodoethane in the presence of a … Why can more than one method be used to synthesize phenacetin? Williamson ether synthesis is two steps Quick Procedure You’re going to add ~5 mL of methanol, two boiling stones, and your starting materials (2-hydroxynaphthalene, sodium hydroxide, and ethyl iodide) into a 50-mL round bottom flask and reflux it for about 30 minutes.

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